Lee was the lead singer in the 1980s and early 1990s for Bob's Your Uncle, a Vancouver alternative rock band. Lee often incorporated performance art techniques into the band's melodic rock. When that band broke up, Lee pursued a solo music career, releasing several solo albums and performing as an actor in theatre, film and television projects.
In 1995, Lee became a VJ for MuchMusic, bringing her theatrical and musical background and her unique creative perspective to the channel. She was best known as the host of MuchMusic's alternative music show, The Wedge. (Now a weekly show, The Wedge was a daily series when Lee hosted.)
In early 2004, she became the centre of controversy when the CBC threatened to fire her for taking a role in John Cameron Mitchell's sexually explicit film Shortbus. However, CBC management relented when their position proved unpopular with CBC listeners.
Lee has also identified as bisexual.
- Tale of Two Legs (1990, with Bob's Your Uncle)
- Cages (1993, with Bob's Your Uncle)
- Lavinia's Tongue (1994)
- Wigs 'n Guns (1996)